منابع مشابه
Supersized lipid droplets
Helping an axon go long A developing neuron has to decide where to grow its axon. Witte et al. show that the choice requires an overlooked ingredient: stable microtubules. As a neuron matures, it sprouts several projections, or neurites. One neurite continues to lengthen and becomes an axon, while the others become dendrites. Although researchers have probed how actin promotes this process, the...
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Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the COPII component Sec31p.
متن کاملOn the Impossibility of Supersized Machines
In recent years, a number of prominent computer scientists, along with academics in fields such as philosophy and physics, have lent credence to the notion that machines may one day become as large as humans. Many have further argued that machines could even come to exceed human size by a significant margin. However, there are at least seven distinct arguments that preclude this outcome. We sho...
متن کاملA Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipids. Little is known about how the size of LDs is controlled, although LDs of diverse sizes have been observed in different tissues and under different (patho)physiological conditions. Recent studies have indicated that the size of LDs may influence adipogenesis, the rate of lipolysis and the oxida...
متن کاملSupersized Atheroma Causing Acquired Coarctation of Aorta Leading to Heart Failure
Calcified atheromatous aortic lesion causing significant narrowing of the aorta is an uncommon clinical entity. This calcified atheroma leads to obstruction of the lumen of the aorta simulating acquired coarctation of aorta causing impaired perfusion of lower limbs, visceral ischemia, and hypertension. We report a case of 58-year-old patient who presented with dyspnea on exertion, orthopnea, pa...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1404827111